average weight loss with semaglutide first month Our weight management program: 12

2025;8(1):e2457349

doi:10.1074/jbc.M802030200

Many GLP-1 users notice: Hollow or gaunt facial features due to volume loss in the cheeks and temples Sagging skin around the jawline and neck (Ozempic face) Flattening of the buttocks (Ozempic butt) Loose skin on the arms, abdomen, or thighs These changes can feel discouraging after such a positive transformation

Since compounded versions of semaglutide usually contain other ingredients, you need to refer to the storage directions for your specific semaglutide formulation

You have conditions or medications where oral absorption could be unreliable

For instance, if a participant shows significant weight reduction at 4 mg, advancing them to 8 mg can help determine whether additional benefits accrue or whether the earlier dose was already sufficient