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Thereafter, the mixtures were all centrifuged and the supernatants were analyzed by LCMS

Creatine supplementation can increase serum creatinine levels independently of true kidney function, potentially affecting eGFR readings

But while these effects work incredibly well for managing weight, having that partially digested food still sitting in your system is exactly what creates complications when it's time for anesthesia

doi:10.1023/A:1026511420505

Current Topics in Medicinal Chemistry, 7 (11), 1098-1106

Perhaps most importantly, most people regain weight after stopping the medication, meaning long-term use may be necessary to maintain results