Like GLP-1, GIP travels through your bloodstream and activates specific GIP receptors in various organs
doi: 10.1001/jama.2022.0078 76 US National Institutes of Health
So when a drug goes under shortage, that essentially gives authority to these compounders to start producing them, you know, to fill in these access gaps
Certainly, human patients with T2DM display a blunted incretin effect of GLP-1, and defects in meal-induced intestinal GLP-1 secretion (91), suggesting that the paracrine action of alpha-cell-derived GLP-1 may be necessary to combat this diminished peripheral incretin action of gut-derived GLP-1
Mitogen-activated protein kinases and reactive oxygen species: how can ROS activate MAPK pathways
"However, exercise provides benefits beyond weight loss, including better mobility and flexibility