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48 In a 5-year follow-up study, only 1 of 10 patients with MRI evidence of CNS melanosis went on to develop neurologic symptoms

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Efficacy: Clinical Trials and Weight Loss Outcomes Seven randomized controlled trials involving 4,795 participants demonstrated significant weight reduction with tirzepatide

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The selected dose range of the study drugs was as recommended for standard therapeutic maintenance treatment, and subjects were dose escalated to semaglutide 1.0 mg steady state to investigate potential interactions at the highest intended treatment dose