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Orlistat is a much more economical option as a weight-loss medication

MOTS-c is typically administered via subcutaneous injection into the abdomen, lateral thigh, or flank, rotating injection sites to prevent tissue accumulation

These include other FDA-approved weight management medications such as phentermine-topiramate (Qsymia), naltrexone-bupropion (Contrave), or orlistat (Xenical, Alli), though these agents generally produce less weight loss than GLP-1 medications

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However, fat cells contain aromatase, an enzyme that creates a weaker form of estrogen