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While IBS itself does not usually cause bloody stool , patients with chronic digestive issues may be more sensitive to the effects of medications like semaglutide

doi: 10.1016/j.diabet.2016.05.009

In type 2 diabetes patients on metformin treatment, AZD5004 led to more side effects than placebo, particularly gastrointestinal in naturethough none of the side effects were serious

Results A total of 11 studies were included in this meta-analysis, including 6 studies on GLP-1 RA, 1 study on GLP-1 and GIP dual receptor agonists, 1 study on orlistat, 2 studies on phentermine-topiramate, and 1 study on naltrexone-bupropion (Additional file 1: Table S2) [22,23,24,25,26,27,28,29,30,31,32]

10.1016/j.msec.2020.110698 73

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