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Striking the balance: GLP-1/Glucagon Co-agonism as a treatment strategy for obesity

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X-ray crystallography and NMR spectroscopy have established that copper coordinates through a 3N1O equatorial square-planar pyramid configuration: the histidine imidazole nitrogen, the glycine -amino nitrogen, and the deprotonated amide nitrogen of the glycine-histidine peptide bond, with additional oxygen coordination from neighboring complex carboxyl groups

P.et al (2022b)

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This helps your body absorb it effectively through the tissue under your tongue