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GLP-1 has a short half-life of only two minutes, due to renal clearance and endogenous GLP-1 is degraded by the enzyme dipeptidyl peptidase IV (DPP-4) (2022)
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In the 1980s, Joel Habener, MD, discovered a gut hormone GLP-1 (glucagon-like peptide-1)that had the potential to stimulate insulin secretion when glucose was elevated, a process generally performed by the pancreas that fails in people with diabetes
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