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doi: 10.3389/fcimb.2021.654813 82 FormanH

Consequently, our data illuminate a novel role of IGF-1 in regulating stress-induced hepatocyte premature senescence in liver fibrosis: prolonged IGF-1 relieves oxidative stress-initiated hepatocyte premature senescence via inhibition of nuclear p53progerin interaction to ameliorate hepatic steatosis and fibrogenesis

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some patients achieve near-normal HbA1c levels Weight loss timeline: Weeks 14: Modest weight loss of 13 kg, primarily reflecting reduced caloric intake due to appetite suppression Months 23: More noticeable weight reduction of 35% of initial body weight Months 36: Continued steady weight loss

Replace electrolytes when you're losing fluid