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However, under a chronic glucolipotoxic environment, persistent hyperglycemia disrupts mitochondrial and endoplasmic reticulum homeostasis to trigger extensive oxidative stress and advanced glycation end-product accumulation, which directly activates various intracellular signaling cascades to initiate RCD pathways (14) ( Table 1 )

Dermatol Surg

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The 8-OHdG concentration in each sample was calculated by five-parameter logistic regression interpolated from the standard curve using elisaanalysis.com software

Possible adverse events include allergic reactions, difficulty breathing, rashes, or changes in blood pressure