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Alisertib shows negligible potential for perpetrating pharmacokinetic drugdrug interactions on ABCB1, ABCG2 and cytochromes P450, but acts as dual-activity resistance modulator through the inhibition of ABCC1 transporter

Insulin-like growth factor-I at physiological concentrations is a potent inhibitor of insulin secretion

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Measurement of AGEs in the skin is a non-invasive method of estimating the cardiovascular mortality, the risk for diabetes complications and also the skin health and the aging process [25]

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