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It is important to mention that the research team took their experimental procedures a step further in order to define the relationship between Dihexa and the PI3K/AKT signaling pathway, wortmannin, a PI3K inhibitor, was administered to the mice intragastrically to detect the number of neuronal cells and inflammatory factors present

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Diabet Med 22:654657 Hinke SA, Kuhn-Wache K, Hoffmann T, Pederson RA, McIntosh CH, Demuth HU (2002) Metformin effects on dipeptidylpeptidase IV degradation of glucagon-like peptide-1

Kalliafas S, Ziegler DW, Flancbaum L, Choban PS (1998) Acute acalculous cholecystitis: incidence, risk factors, diagnosis, and outcome

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mAbs such as PRX004 and NI301A offer a promising strategy for ATTR-CM treatment by selectively binding to both wild-type and mutant TTR amyloid fibrils, thereby promoting the clearance of existing amyloid deposits