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This ceramide deficiency means that acid molecules penetrate deeper and faster than they would in intact skin, reaching the viable epidermis at concentrations that are irritating or damaging rather than therapeutic

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However, the levels of other metabolites such as 5-Aminolevulinate, cysteate, putrescine, 4-Aminobutyraldehyde, kynurenine, serotonin, Formyl-5-hydroxykynurenamine, 5-Hydroxykynurenine, 2-Aminomuconate, xanthine, and 5-Aminolevulinate were significantly increased in LC patients ( Figure 3C , Supplementary Figure 3A )

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