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Weekly monitoring during escalation: During dose increases, measure resting heart rate each morning using the same protocol

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Plasma levels decline with age from about 200 ng/mL at age 20 to roughly 80 ng/mL by age 60

The peptide exhibits consistent efficacy in models of acute and chronic injury regardless of administration route (intraperitoneal, oral, or local application), a unique characteristic distinguishing it from other growth factors that typically require localized delivery with carrier systems