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In real-world practice, side effects loom even larger patients may not have close monitoring or reassurance, and frequently self-discontinue when persistent nausea or other issues make them feel worse before they feel better
Timing of administration may also influence tolerability
To put it into perspective, the use of semaglutide was associated with a 36% lower risk of hospitalization and liraglutide was associated with a 28% lower risk
95% CI, 0.86-1.05) and all-cause mortality (HR = 1.04
increasing hydration
Volume depletion is a key concern, as it may precipitate acute kidney injury
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