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Additionally, elevated levels of the plasma amino acid homocysteine can be a functional marker of folate, vitamin B12, or vitamin B6 deficiency, as all these vitamins are required to convert homocysteine into methionine

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Gastrointestinal symptoms dominate

Expect to wait at least 48 weeks of consistent use before seeing noticeable differences

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Evidence quality was moderate for cardiovascular death, all-cause death, nonfatal stroke, unstable angina hospitalization, and high for the remainder