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Vitamin C serves as an essential cofactor for collagen production and can be obtained through diet or supplementation

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Cu ions are bound by proteins like metallothioneins and ceruplasmin, which stops it from catalysing the breakdown of hydroperoxides into free radicals [212, 213]

Possible clinical applications are women with central obesity, HIV-associated lipodystrophy, or metabolic syndrome in which visceral fat negatively affects reproductive outcomes

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