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Artemisinin suppresses aerobic glycolysis in thyroid cancer cells by downregulating HIF-1a, which is increased by the XIST/miR-93/HIF-1a pathway

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Diaz-Hernandez JI, Almeida A, Delgado-Esteban M, Fernandez E, Bolanos JP

However, arginine level depletion in patients sustained for about a week and returned to baseline level, suggesting that resistance on ADI-PEG20 may arise upon prolonged drug treatment [140, 141]