Constitutive activation of NRF2, mainly via loss-of-function mutations in the CUL3-adapter KEAP1 or gain-of-function mutations in NFE2L2 , is thought to provide a fitness advantage to tumor cells in confronting metabolic/oxidative stress resulting from dysregulated growth (DeNicola et al, 2011
Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E
Helps in reducing hyperpigmentation and melasma
In normal physiology, the majority of circulating IGF-1 is bound to IGFBP-3, forming a large ternary complex with the acid-labile subunit that prevents rapid clearance and buffers free IGF-1 within a tightly controlled range
However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers
10.1080/08923973.2019.1569049 104 WangJ.LuoW.LiB.LvJ.KeX.GeD.et al (2018)