Yes, chelation therapy has been studied in clinical trials, including the TACT (Trial to Assess Chelation Therapy) for heart disease
Clinicians must, therefore, extrapolate from established principles for GLP-1 switching namely, avoiding direct dose equivalence and prioritising patient safety as per individual drug summary of product characteristics
Tirzepatide adds GIP activation, which slightly alters the profile
These medications are protein-based, so they need to be injected into the subcutaneous fat layer the soft tissue between the skin and muscle
Whatever method helps you stick to your plan will generally work best
Nausea and stomach discomfort can intensify when lying down flat, making it harder to find a comfortable sleeping position