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DSIP also modulates the hypothalamic-pituitary-adrenal (HPA) axis, which controls the release of stress hormones like cortisol and adrenocorticotropic hormone (ACTH)

When used as a monotherapymeaning its taken on its own, without being combined with other medicationsits currently being tested in a large phase 3 clinical trial program called RENEW

Angew Chem Int Ed Engl

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PMC 4309183

In the UK, typical oral doses for dietary deficiency are 50-150 micrograms daily, with higher doses (1000-2000 micrograms) generally reserved for clinical situations under healthcare supervision