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doi: 10.1007/s00125-022-05715-4 23 DahlDOnishiYNorwoodPHuhRBrayRPatelHet al

These came up short of expectations, but there were also winners -Bristol Myers Squibbs LAG3 (Opdualag) + CTL4 (Yerovy), both of which are expected to be multi-billion dollar drugs

Baseline liver enzyme assessment is reasonable for patients with: Pre-existing liver disease or elevated baseline transaminases Metabolic syndrome or clinical features suggesting MASLD Concurrent use of other potentially hepatotoxic medications Obesity (BMI 30 kg/m) with additional metabolic risk factors History of excessive alcohol consumption For patients with abnormal baseline liver enzymes, periodic monitoring every 3-6 months during the first year of therapy allows clinicians to assess treatment response and detect any unexpected changes

Data presented in this analysis represent raw counts and/or rates, and post-stratification methods have not been conducted.

Taking the Wegovy pill has only 1-3% bioavailability , and reaches peak saturation in your bloodstream within hours

The lipid conjugate drives reversible albumin binding in plasma-stability assays