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Once-daily oral administration of ID110521156 in diabetic monkeys resulted in reduced plasma glucose levels, increased insulin secretion, decreased food intake, and weight loss
Among these, glucagon-like peptide-1 (GLP-1) receptor agonists, which are already approved for weight management and type 2 diabetes, have shown promise
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Reimann F, Diakogiannaki E, Hodge D, Gribble FM
Explaining this disproportionate relationship further, Professor Lawley said clinical trial data for GLP-1 treatments show situations where increases to the dose size do not provide indication of a corresponding level of efficacy improvement of the same magnitude
