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Unlike the reigning blockbuster GLP-1 drugs on the market namely Novo Nordisks Wegovy (semaglutide) and Eli Lillys Zepbound (tirzepatide), the latter of which is a dual agonist of the GLP-1 and GIP receptors Amgens MariTide is an antibody-peptide conjugate that combines a GLP-1 receptor agonist (consisting of two peptides that mimic the GLP-1 hormone) and GIP receptor antagonist (an antibody that blocks the receptor)
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According to FDA labeling, no dose adjustment is required in patients with renal impairment, including those with end-stage renal disease (ESRD)
More importantly, if left unchecked, insulin resistance can pave the way for prediabetes and type 2 diabetes
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mild nausea may occur Weeks 5-8: Increase to 0.5 mg
Third, it builds tolerance so that when you reach therapeutic doses, the side effects are manageable rather than overwhelming
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