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In contrast to common obesity, where cardiovascular risk reduction drives intervention, the main rationale for treatment in MC4R -deficient patients shifts toward alleviating mechanical complications (e.g., sleep apnea, osteoarthritis), preventing diabetes (hyperinsulinemia is common despite relative euglycemia), and improving quality of life [30]

It participates in building muscle and breaking down fat

Buhner S, Buning C, Genschel J, Kling K, Herrmann D, Dignass A, et al

Because the drugs are so widely prescribed and expensive, Hashmi said it's important to understand how patients are using these drugs to lose weight and whether they're achieving health benefits

Treatment decisions are based on individual clinical assessment

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