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The radiotracer locates and binds to the receptor of interest and it is important that the imaging agent does not lead to significant receptor occupation [298]
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Its expression has been linked to the capacity of breast cancer cells to control their redox state by promoting the accumulation of reduced glutathione, thereby decreasing ROS levels and increasing cell survival (Table 1)
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PMID 6206240
(A) Cells were pretreated with or without GLP-1 (10 nM) for 1 h in the presence or absence of Ex-9 (10 nM), incubated with H 2 O 2 (1 mM) for 12 h, and then stained with primary antibodies of LC3II followed by staining with secondary antibodies
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