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While enrollment in the dose-finding portion had begun, the CRLs indicate that the confirmatory portions of these trials should be underway, Regeneron stated

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doi: 10.1080/19420862.2025.2490788

However, attempts were also made to stabilise the GLP-1 molecule against DPP-4 and also to prevent its high renal clearance rate, which in itself would result in an IV half-life of 30 min