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Unfortunately, targeting of -secretase produced some undesirable side effects, because of its physiological role in the cleavage of multiple transmembrane protein substrates (Periz and Fortini, 2004), and its control over many biological processes, such as cell differentiation, proliferation, and/or survival

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The obesity/chronic weight management segment is expected to grow at the fastest CAGR during the forecast period, fueled by growing awareness of obesity as a chronic illness and rising obesity rates worldwide

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A -Lg derived tri-peptide (IleProAla) can be released from -Lg by digestion with proteinase K ( Reference Abubakar, Saito and Kitazawa 75 ) and when evaluated in vitro it was found to have an IC 50 value of 49 m ( Reference Tulipano, Sibilia and Caroli 65 )

Trial of antisense oligonucleotide tofersen for SOD1 ALS