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PubMed 3

But before we dive into the science, lets first understand melanin

1 Riehls melanosis (RM) is an acquired hyperpigmentation disorder, presenting diffused and reticulate brownish-gray pigmentation, preferentially on the face and neck, and the histopathological features include basal cell liquefactive degeneration, dermal melanin incontinence and/or lymphohistiocytic infiltrate, and upper dermal melanophage infiltration

It is supplied for use in controlled laboratory environments to support the preparation, dilution, and handling of research compounds under aseptic conditions

Effects fade when you stop, and chasing permanence with continued high-dose injections is where the safety risk climbs