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More specifically, the reactive oxidative species (ROS) affect microenvironments associated with the fluid surrounding the egg, fallopian tube fluid, and abdominal fluid and have a direct bearing on egg quality (cell membranes, mitochondria & DNA), sperm-egg interaction (fertilization), sperm-mediated egg activation, implantation, and early embryo development

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If any step of the process is disrupted, the activity of GPX4 will decrease, resulting in the accumulation of intracellular peroxides, which contributes to ferroptosis

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PMID: 9725921 Sharer N.M, Taylor P.M, Linaker B.D, Gutteridge J.M.C, Braganza J.M

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