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Evidence suggests that reducing obesity at a population level requires action on the environments which shape daily life

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Treatment group and time point post-PBS or LPS treatment were included as variables in the design matrix

They can be useful when an approved drug cannot meet a particular patients needs, but they also carry additional risks

In short: TRIUMPH-3 shows retatrutide can be used safely in a cardiovascular disease population without signal of harm, but the question of whether it actively reduces heart attacks and strokes remains open until TRIUMPH-Outcomes reports

First, rising obesity and type 2 diabetes prevalence is increasing the need for therapies that address weight and glucose together