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Some people choose the thigh as their primary injection site

Cost: The average cost of metformin without insurance ranges from as low as $10 per month for tablets to up to $400 per month for the liquid solution

This is not a flaw in the medication

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Morbidity improvements are generally lower than mortality improvements due to a higher proportion of morbidity incidence (in a critical illness product) being caused by cancers (where the relative risks of incidence by BMI are lower), compared to mortality, with a higher proportion of deaths caused by CVD (where the relative risks by BMI are higher)