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Participants in the SGLT2i group demonstrated improvement in renal function with an increase in mean eGFR over the 5-year follow-up period (+3.5 ml/min per 1.73 m 2 ), compared with an overall reduction in eGFR in the GLP-1 RA cohort (7.2 ml/min per 1.73 m 2 )

Glycaemic outcomes were equally striking: 7782% of participants on retatrutide achieved euglycaemia (HbA1c 6.5%), and between 5763% achieved body weight reductions of 15% or more

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