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According to the American Diabetes Association (ADA), metformin remains the preferred first-line therapy for T2DM (19)

File the claim: With sufficient evidence, your legal team can then file the claim in the appropriate jurisdiction

If fatigue coincides with these changes, it is likely drug-related

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If patients cannot tolerate a dose increase, the escalation may be delayed

Note, no head-to-head studies of GLP-1RAs and SGLT-2 inhibitors or acarbose are available

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