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Lets go back in time to the mid 1920s when the Nobel prize for medicines recipients had received the honour for discovering that patients with Pernicious Anaemia could be kept alive by giving them raw or slightly cooked liver

In AITD, borderline or low B12 levels are reported

fragment-specific activity review: PMC8724243 KPV NF-B inhibition blocks nuclear translocation of NF-B, suppresses TNF-/IL-6/IL-8/IL-1 transcription, preserves normal immune signaling: PubMed 18061177 KPV PepT1-mediated uptake in inflamed tissue Dalmasso G et al

Niacinamide also demonstrated a protective effect against post-inflammatory hyperpigmentation: unlike in the benzoyl peroxide-only group, post-acne pigmentation did not increase significantly with the combination, suggesting a modulating effect on melanin production in inflammatory contexts

it's produced by bacteria in the gut and when we consume certain animal foods, we get the B12 produced by the gut bacteria of those animals