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Independence from glucose control : In SELECT participants without diabetes, cardiovascular risk reduction was consistent across baseline HbA1c subgroups and across categories of HbA1c change from baseline to 20 weeks, confirming that the benefits don't depend on blood sugar improvements either

JAMA 270:22002204 Dohil R, Cabrera BL (2013) Treatment of cystinosis with delayed-release cysteamine: 6-year follow-up

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The trade-off is that slower escalation means slower weight loss initially, but the improved tolerability often leads to better long-term adherence and outcomes