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The Phase 2 retatrutide trial (PMID 37366315) reported -24.2% body weight change at the 12 mg weekly dose across 48 weeks

Bosma PJ, Chowdhury JR, Huang TJ, Lahiri P, Elferink RP, Van Es HH et al

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clinician-assessed measurements of functions are subjective and may not be reliable indicators in trials of early-stage ALS patients