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In emergency medicine training, dose discussions also make more sense when tied to route, indication, and timing rather than memorized in isolation
Estimating this rather than working out the actual figure makes it difficult to keep dosing consistent across a research timeline, which undermines the reliability of any comparison drawn between sessions
High-risk patient factors include active gastrointestinal symptoms (odds ratio 7.66, 95% confidence interval 3.4217.17), early treatment phase (less than 4 weeks), higher medication doses, pre-existing diabetic gastroparesis, obesity (BMI greater than 30), and gastroesophageal reflux disease [31]
There are also reports of seasonal variation in thyroid function
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