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Most GLP-1 agonists (semaglutide, liraglutide, dulaglutide, tirzepatide) do not require dose adjustment for mild-to-moderate renal impairment, though caution is warranted in severe renal impairment

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It has not been evaluated by bodies like the United States Food and Drug Administration (FDA) or comparable international agencies, leading to a significant gap in understanding its safety for human use

This can increase sodium and water excretion and may slightly reduce circulating blood volume