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Two-year total mortality was 0.09 death per person-year for the LVRS group versus 0.10 death per person-year in the medical therapy group (risk ratio 0.89

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8, 9, 10 This has been linked to chronic low-level inflammation induced by pro-inflammatory cytokines released by the tumor and tumor-associated macrophages (see review on cachexia in the same issue of this topical issue)

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85 Elafibranor was associated with a mild reversible rise in serum creatinine but had no adverse effects on cardiac profile or body weight