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Patients taking medication for lifestyle-related comorbid diseases, such as hypertension, dyslipidemia, and diabetes, were included

It is believed to interact with several areas of the central nervous system, including the hypothalamus, where it influences human circadian rhythms and the initiation of sleep

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Drug-metabolizing enzymes chemically modify a variety of substituents on drug molecules, thereby either rendering the drugs inactive or facilitating their elimination by increasing solubility and ultimately excretion in the urine or bile