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Algunos pacientes encuentran que la administracin nocturna les permite "dormir durante" estos sntomas, mientras que otros prefieren la maana para poder manejar cualquier malestar mientras estn despiertos y tienen acceso a alimentos o medicamentos sintomticos

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Amide bond Ester bond is relatively weaker than amide bond, it will be rapidly hydrolyzed by esterase enzyme Example Procaine Short acting local anesthetic Procainamide Long acting antiarrhythmic T1/2 = 40-84 second T1/2 = 2.5-4.5 hr Hydrolytic phase-I metabolism Examples of prodrugs activated by hydrolytic enzymes: Dipivefrine: is a di-tertbutylcarboxy ester of adrenaline