During drug development studies, a 40% decrease in etravirine concentration was observed when coadministered with efavirenz.10 This drug interaction seems to be mediated by the inductive effect of efavirenz on CYP3A4, one of the main enzyme involved in etravirine metabolism
conducted the present pilot study [2] to examine the ratio of acylcarnitines to free carnitines (AC/FC), a biomarker of cardiomyocyte carnitine insufficiency and impaired -oxidation [3], either in symptomatic HF with reduced left ventricular ejection fraction (LVEF) HFrEF or HF with preserved LVEF (HFpEF), and demonstrated that AC/FC levels in admission were significantly higher than in asymptomatic staged HF, decreasing to comparable levels at discharge
Between-study heterogeneity was evaluated using the 2 based Q-test and I 2
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Brain and Behavior, 6(3), 211-223