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10 List of small molecule GLP-1R modulators with available structures

"The FDA recently stated that their 'preliminary evaluation has not found evidence that use of these medicines causes suicidal thoughts or actions.' Similarly, our reviews of the clinical trials, including large outcome studies and observational studies, did not find an association between use of GLP-1 receptor agonist medicines and the occurrence of suicidal thoughts or actions

The key clinical message is that no safety signal for increased suicidality was observed