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After 3 min of habituation, mice were subjected to an electric foot shock (0.75 mA, 3 s) simultaneously to a tone (2.5 kHz, 85 dB, 3 s) and returned to their home cages
Ethics declarations Ethical approval and informed consent The trials adhered to the principles of the Declaration of Helsinki and received approval from an independent ethics committee or institutional review board at each participating site
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3.3 Parkinsons disease PD is a neurodegenerative disorder that typically presents later in life with generalized bradykinesia and another symptom of resting tremor or rigidity
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