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Why Some Patients Split Their GLP-1 Dose Many patients tolerate once-weekly injections very well

Importantly, no direct causal evidence has been demonstrated in human RCTs

Advice for Healthcare Professionals The MHRA Drug Safety Update provides the following key guidance for healthcare professionals: Semaglutide treatment may be very rarely associated with NAION, which can cause vision loss, typically in one eye NAION typically presents as sudden, painless vision loss described as blurring or cloudiness Privately prescribed semaglutide may not appear on a patients medical record if a patient presents with these symptoms, enquire about semaglutide use Patients reporting sudden loss of vision (including partial loss) should be urgently referred for specialist examination by an ophthalmologist Discontinue semaglutide treatment if NAION is confirmed Advise new patients, or existing patients during medication reviews, to urgently attend eye casualty or A&E if they experience sudden vision loss or rapidly worsening eyesight An alert advised healthcare professionals to be vigilant for further issues, including rare but serious side effects such as acute pancreatitis

doi: 10.3389/fnut.2025.1508441 Received 16 April 2025 Accepted 07 August 2025 Published 29 August 2025 Volume 12 - 2025 Edited by Marija Takic, University of Belgrade, Serbia Reviewed by Miljana Z

Wegovy and other GLP-1 receptor agonists have also been linked to an increased risk of acute pancreatitis, gallbladder problems, acute kidney injury, low blood sugar, diabetic retinopathy complications, increased heart rate, and suicidal thoughts

Keep the tablet between your cheek and gum until completely dissolved