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Thus, the results of the studies show that spermidine has the potential to prolong life, protecting both the nervous and cardiovascular systems (Reference Li, Tian and Guo89)

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Thyroid function changes Some studies and case reports suggest GLP-1s may lower thyroid stimulating hormone (TSH) levels, possibly through direct effects on the hypothalamic-pituitary-thyroid (HPA) axis, and delayed gastric emptying (affecting medication absorption)

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Artificial sweeteners: Sorbitol, mannitol, xylitol, and maltitol have osmotic effects that draw water into the intestines