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We hypothesise that a few mechanisms may have contributed to the observed cardioprotective effects of GLP-1RAs in our study: (1) this class of glucose-lowering drugs induces weight loss, which has a positive impact and results in a better cardioprotective effect

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GutBrain Axis 101: Serotonin, 5HTP & Digestive Signaling Why 90 % of Serotonin Lives in Your Gut GLP-1s affect more than your gut

Melanotan 2 is a synthetic analog of melanocyte stimulating hormone (-MSH), a natural hormone responsible for stimulating pigment cells in the skin to produce more melanin

However, others propose that respiratory inhibition negatively affects ATP production via subsequent effects on mitochondrial depolarization ( Alternatively, there is the notion that NO advantageously affects mitochondrial efficiency (Pappas et al., 2023)

Protecting against oxidative stress 4