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Active eating disorders : Underlying eating disorders like bulimia nervosa or anorexia nervosa may worsen as a result of Semaglutide GLP-1 effects on metabolism and weight loss

There's also a hunger-hormone angle: ghrelin, the "hunger hormone" produced by the stomach when it's empty, is decreased by GLP-1 receptor agonists, which contributes to their appetite-suppressing effects

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The incidence correlates with delays in initiating therapy with NAC

This ratio of GSH: GSSG is maintained by the action of GSSG reductase, which requires NADPH+ as the reducing cofactor