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Additionally, inflammation in the gut may disrupt communication between intestinal cells and the endocrine system, affecting hormones that regulate appetite and energy expenditure
G.et al (2001)
This senescence can further enhance inflammation by releasing senescence-associated secretory phenotype (SASP) factors, which induces a feedback loop between inflammation and telomere attrition (Herranz and Gil, 2018)
It is important to consider the potential confounding effects of concurrent glucose reduction with DPP4 inhibitors when analyzing preclinical investigations